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The drug orlistat is associated with the least-severe adverse effects, but compared with other drugs in its class it also delivers the most modest weight loss versus placebo less than 3 kg .
Information about Orlistat.
Rare cases of increase in transaminases and in alkaline phosphatase and hepatitis that may be serious have been reportedThere have been reports of hepatic failure observed with the use of XENICAL in postmarketing surveillancewith some of these tryptizol. cases resulting in liver transplant or deathsee WARNINGS AND PRECAUTIONSRare cases of hypersensitivity have been reported with the use of XENICALSigns and symptoms have included pruritusrashurticariaangioedemabronchospasm and anaphylaxisVery rare cases of bullous eruption have been reportedRare cases of leukocytoclastic vasculitis have been reportedClinical signs include palpablepurpuramaculopapular lesionsor bullous eruptionAcute oxalate nephropathy after treatment with XENICAL has been reported in patients with or at risk for renal diseasesee WARNINGS AND PRECAUTIONSPancreatitis has been reported with the use of XENICAL in postmarketing surveillanceNo causal relationship or physiopathological mechanism between pancreatitis and obesity therapy has been definitively establishedLower gastrointestinal bleeding has been reported in patients treated with XENICALMost reports are nonserioussevere or persistent cases should be investigated further.
If you also take cyclosporinedo not take it within 3 hours before or 3 hours after you take orlistat.
Patients should be strongly encouraged to take a multivitamin supplement that contains fat-soluble vitamins to ensure adequate nutrition because XENICAL has been shown to reduce the absorption of some fat-soluble vitamins and beta-carotenesee DOSAGE AND ADMINISTRATIONand ADVERSE REACTIONSIn additionthe levels of vitamin D and beta-carotene may be low in obese patients compared with non-obese subjectsThe supplement should be taken once a day at least 2 hours before or after the administration of XENICALsuch as at bedtime.
Orlistat is a reversible inhibitor of gastrointestinal lipasesIt exerts its therapeutic activity in the lumen of the stomach and small intestine by forming a covalent bond with the active serine residue site of gastric and pancreatic lipasesThe inactivated enzymes are thus unavailable to hydrolyze dietary fat in the form of triglycerides into absorbable free fatty acids and monoglyceridesAs undigested triglycerides are not absorbedthe resulting caloric deficit may have a positive effect on weight control.
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plasma concentrations of orlistat and its metabolites m1 and m3 were similar to those found in adults at the same dose level.